Researchers have discovered that a gene previously seen as a biomarker for Alzheimer's disease, PHGDH, actually plays a causal role by disrupting gene regulation in the brain. Using AI, the team revealed that PHGDH has a hidden DNA-binding function unrelated to its known enzymatic activity. This malfunction triggers early Alzheimer's development, offering a new target for prevention.
Researchers have discovered that a gene previously seen as a biomarker for Alzheimer's disease, PHGDH, actually plays a causal role by disrupting gene regulation in the brain. Using AI, the team revealed that PHGDH has a hidden DNA-binding function unrelated to its known enzymatic activity. This malfunction triggers early Alzheimer's development, offering a new target for prevention.
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